Qiagen AVL Buffer safety data sheet

Qiagen RNA extraction kits use AVL buffer. AVL buffer has 50-70% guanidinium isothiocyanate according to their safety data sheet. Their website doesn’t let you link directly to the safety data sheet as the url expires after some time; so I’ve saved it in (the amazing) internet archive: https://web.archive.org/web/20200414164736/https://sds.qiagen.com/ehswww/QIAGENwww/result/report.jsp?P_LANGU=E&P_SYS=4&P_SSN=42571&P_REP=00000000000000000090&P_RES=756783

Hazardous ingredients

Chemical NameCAS-No.Concentration (% w/w)
guanidinium thiocyanate593-84-0= 50 – < 70

It’s important to note that they don’t share what else is in the AVL buffer. And that there’s research to show this buffer may be insufficient to inactivate some viruses: https://jcm.asm.org/content/53/10/3148 “Buffer AVL Alone Does Not Inactivate Ebola Virus in a Representative Clinical Sample Type”

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